Synthesis and spectroscopic studies of some
Triazolopyrimidines and Pyrimidotriazines
المؤلفون:
Al Haiza Mohamed Ali
تاريخ النشر:
2004
الاستشهاد المرجعي :
Synthesis and spectroscopic studies of some
Triazolopyrimidines and Pyrimidotriazines Mohamed A AlHaiazaKing Khalid University Journal natural medical technical sciencesVol 1 no 1 (1425 H 2004) p p 520Al Haiza Mohamed Ali
الملخص:
Further substitution of 2alkylthio34dihydro4oxo6phenylpyrimidines (1a b)
yielded the N3substituted pyrimidine derivatives (2ag) Compounds (2e f) reacted
with hydrazine to form the pyrimido[2 1c] triazines (6a b) Also treatment of the 2
hydrazinopyrimidine derivative (7) with chloroacetyl chloride produced the
hydroxyprimidotriazine derivative (8) Desulphurisation of compound (1a) with
benzhydrazide resulted in the formation of the 2(2benzoylhydrazio)pyrimidine
derivative (12) which could be cyclised into the triazolo [43a] pyrimidine (13) The
latter compound could also be synthesised by two other different alternative routes
Compound (1a) reacted with semicarbazide to afford directly the
dioxotriazolopyrimidine (16) Compound (16) could also be obtained by two other
different methods The isomeric compound (17) of (16) could also be prepared from
(7) and cyanogen bromide