Use of collagen breakdown products in the diagnosis of some connective tissue diseases
Auteur(s):
Siddiqi Nikhat J AlOmairini Eman A AlAfaleg Nouf O
Date de publication:
2009
Référence bibliographique:
Use of collagen breakdown products in the diagnosis of some connective tissue diseases Eman A AlOmairini Nouf O AlAfaleg and Nikhat J Siddiqiمجلة جامعة الملك سعود مجلة العلوم عمادة شؤون المكتبات، جامعة الملك سعودVol 21 (2009 1430 H) p p 6773AlOmairini Eman AAlAfaleg Nouf OSiddiqi Nikhat J
Résumé:
Collagen is the most abundant protein in the extracellular matrix and connective tissue There are more than 20 different types of collagen each with a basic structure consisting of triple helix made of three polypeptide chains Functions of collagen include tissue scaffolding providing mechanical strength tensile stiffness etc During rapid growth and in diseases like arthritis osteoporosis paget's disease metastatic bone disease and renal osteodystrophy the extent of collagen degradation is quite extensive Collagen breakdown products released in the body fluids during diseases can be used to measure the rate of collagen breakdown Collagen breakdown products which could be used as disease markers include pyridinium crosslinks pyridinoline (hydroxylysyl pyridinoline) deoxypyridinoline (lysyl pyridinoline) peptidebound cross linked Ctelopeptide peptidebound crosslinked Ntelopeptide and hydroxyproline The clinical role of these biochemical markers could include early diagnosis monitoring disease progression monitoring the therapeutic progress predicting the disease outcome and selection of optimal therapy
